A new inherited abnormality of human erythrocytes - elevated erythrocytic adenosine triphosphate
نویسندگان
چکیده
منابع مشابه
Adenosine triphosphate restoration and discocytic transformation of stored human erythrocytes.
Erythrocytes in human blood stored for 120 days were collected by centrifugation after dispersion in buffered physiological saline. The aged erythrocytes thus collected were incubated with inosine, adenine, glucose or other media, and their shapes and ATP levels were studied by scanning electron microscopy and a luciferine-luciferase method. The aged erythrocytes incubated in a mixture of adeni...
متن کاملThe elevation of adenosine-triphosphate levels in human erythrocytes.
It has previously been possible to double the level of ATP in human erythrocytes by incubation of the cells at 37 for 1 0 hr with glucose and adenine. The present study describes a further increase in the ATP level and some of the possible mechanisms involved. Addition of 5 mM pyruvate to a medium containing 32 mM inorganic phosphate, glucose. and adenine elevated the level of ATP threefold dur...
متن کاملTime-dependent loss of adenosine 5'-monophosphate deaminase activity may explain elevated adenosine 5'-triphosphate levels in senescent erythrocytes.
Senescent erythrocytes from rabbits were previously shown to have elevated levels of adenine nucleotides. The present study documents that aged red blood cells have a normal synthetic capacity for adenine nucleotides, as indicated by normal levels of adenosine kinase. However, senescent erythrocytes do have decreased levels of adenosine 5'-monophosphate deaminase, the critical enzyme involved i...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 1965
ISSN: 0006-291X
DOI: 10.1016/0006-291x(65)90726-6